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Additionally, nicotine can increase the risk of thrombosis through the increased cellular expression of the pro-inflammatory cytokine TNF- and plasminogen activator inhibitor-1, as well as the downregulation of NrF2, which regulates the antioxidative response system, and thrombomodulin, responsible for the crucial anticoagulant properties of thrombin (Lau et al., 2006

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However, following several studies among popcorn factory workers that link the inhalation of diacetyl to respiratory diseases, a controversy was born, and its use in electronic cigarettes started to be debated

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